Glucocorticoids regulate thrombopoiesis by remodeling the megakaryocyte transcriptome.

ABSTRACT:

Background

Glucocorticoids are widely known for their immunomodulatory action. Their synthetic analogs are used to treat several autoimmune diseases, including immune thrombocytopenia. However, their efficacy and mechanisms of action in immune thrombocytopenia are not fully understood.

Objectives

To investigate the mechanism of glucocorticoid actions on platelet production.

Methods

The actions of glucocorticoids on platelet production were studied combining in vivo, ex vivo and in vitro approaches.

Results

Dexamethasone reduced bleeding in mice and rapidly increased circulating young platelet counts. In vitro glucocorticoid treatment stimulated proplatelet formation by megakaryocytes and platelet-like particle release. This effect was blocked by glucocorticoid

SUBMITTER: Grodzielski M 

PROVIDER: S-EPMC10592358 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature