Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals.

ABSTRACT:

Introduction

Phosphorylated tau (p-tau) biomarkers have been recently proposed to represent brain amyloid-β (Aβ) pathology. Here, we evaluated the plasma biomarkers' contribution beyond the information provided by demographics (age and sex) to identify Aβ and tau pathologies in individuals segregated as cognitively unimpaired (CU) and impaired (CI).

Methods

We assessed 138 CU and 87 CI with available plasma p-tau231, 217⁺ , and 181, Aβ42/40, GFAP and Aβ- and tau-PET.

Results

In CU, only plasma p-tau231 and p-tau217⁺ significantly improved the performance of the demographics in detecting Aβ-PET positivity, while no plasma biomarker provided additional information to identify tau-PET positivity. In CI, p-tau217⁺ and GFAP significantly co

SUBMITTER: Ferreira PCL 

PROVIDER: S-EPMC10592380 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature