Longitudinal rates of atrophy and tau accumulation differ between the visual and language variants of atypical Alzheimer's disease.

ABSTRACT:

Introduction

Atypical variants of Alzheimer's disease (AD) include the visual variant, known as posterior cortical atrophy (PCA), and the language variant, known as logopenic progressive aphasia (LPA). Clinically, rates of disease progression differ between them.

Methods

We evaluated 34 PCA and 29 LPA participants. Structural magnetic resonance imaging and ¹⁸ F-flortaucipir positron emission tomography were performed at baseline and at 1-year follow-up. Rates of change in tau uptake and grey matter volumes were compared between PCA and LPA with linear mixed-effects models and voxel-based analyses.

Results

PCA had faster rates of occipital atrophy. LPA had faster rates of left temporal atrophy and faster rates of tau accumulation in the parietal, right tempo

SUBMITTER: Sintini I 

PROVIDER: S-EPMC10592409 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature