Bayesian optimization of tacrolimus exposure in stable kidney transplant patients.

ABSTRACT:

Study objective

The objective was to compare tacrolimus AUC_0-12 determined by Non-Compartmental Analysis (NCA) using intensive sampling to Maximum a Posteriori-Bayesian (MAP-Bayesian) estimates from robust (n = 9 samples/subject) and sparse (n = 2 samples/subject) sampling in 67 stable KTRs and a validation group of similar patients.

Design

This open-label, prospective, single center 12-h PK study included nine serial samples collected in KTRs to determine steady-state NCA tacrolimus AUC_0-12 .

Setting

This study was conducted at a single site within a large, urban hospital in the western New York area.

Patients

This study described tacrolimus pharmacokinetics in stable kidney transplant recipients on maintenance tacrolimus therapy.

Inte

SUBMITTER: Nguyen TD 

PROVIDER: S-EPMC10592415 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature