Racial differences in low natriuretic peptide levels: Implications for heart failure clinical trials.

ABSTRACT:

Background

Some patients with heart failure (HF) have low natriuretic peptide (NP) levels. It is unclear whether specific populations are disproportionately excluded from participation in randomized clinical trials (RCT) with inclusion requirements for elevated NPs. We investigated factors associated with unexpectedly low NP levels in a cohort of patients hospitalized with HF, and the implications on racial diversity in a prototype HF RCT.

Methods

We created a retrospective cohort of 31,704 patients (age 72 ± 16 years, 49% female, 52% Black) hospitalized with HF from 2010 to 2020 with B-type natriuretic peptide (BNP) measurements. Factors associated with unexpectedly low BNP levels (<50 pg/mL) were identified using multivariable logistic regression models. We simulated patie

SUBMITTER: Gangavelli A 

PROVIDER: S-EPMC10592492 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature