Polysialylation controls immune function of myeloid cells in murine model of pneumococcal pneumonia.

ABSTRACT: Polysialic acid (polySia) is a post-translational modification of a select group of cell-surface proteins that guides cellular interactions. As the overall impact of changes in expression of this glycan on leukocytes during infection is not known, we evaluate the immune response of polySia-deficient ST8SiaIV^-/- mice infected with Streptococcus pneumoniae (Spn). Compared with wild-type (WT) mice, ST8SiaIV^-/- mice are less susceptible to infection and clear Spn from airways faster, with alveolar macrophages demonstrating greater viability and phagocytic activity. Leukocyte pulmonary recruitment, paradoxically, is diminished in infected ST8SiaIV^-/- mice, corroborated by adoptive cell transfer, microfluidic migration experiments, and intravital microscopy, and

SUBMITTER: Shinde P 

PROVIDER: S-EPMC10592499 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature