Time-dependent diffusion tensor imaging and diffusion modeling of age-related differences in the medial gastrocnemius and feasibility study of correlations to histopathology.

ABSTRACT:

Purpose

Implement STEAM-DTI to model time-dependent diffusion eigenvalues using the random permeable barrier model (RPBM) to study age-related differences in the medial gastrocnemius (MG) muscle. Validate diffusion model-extracted fiber diameter for histological assessment.

Methods

Diffusion imaging at different diffusion times (Δ) was performed on seven young and six senior participants. Time-dependent diffusion eigenvalues (λ₂ (t), λ₃ (t), and D_⊥ (t); average of λ₂ (t) and λ₃ (t)) were fit to the RPBM to extract tissue microstructure parameters. Biopsy of the MG tissue for histological assessment was performed on a subset of participants (four young, six senior).

Results

λ₃ (t) was significantly highe

SUBMITTER: Malis V 

PROVIDER: S-EPMC10592510 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature