Suppression of Heart Failure With PAR1 Pepducin Technology in a Pressure Overload Model in Mice.

ABSTRACT:

Background

PAR1 (protease-activated receptor-1) contributes to acute thrombosis, but it is not clear whether the receptor is involved in deleterious inflammatory and profibrotic processes in heart failure. Here, we employ the pepducin technology to determine the effects of targeting PAR1 in a mouse heart failure with reduced ejection fraction model.

Methods

After undergoing transverse aortic constriction pressure overload or sham surgery, C57BL/6J mice were randomized to daily sc PZ-128 pepducin or vehicle, and cardiac function, inflammation, fibrosis, and molecular analyses conducted at 7 weeks RESULTS: After 7 weeks of transverse aortic constriction, vehicle mice had marked increases in macrophage/monocyte infiltration and fibrosis of the left ventricle as compared with Sh

SUBMITTER: Fletcher EK 

PROVIDER: S-EPMC10592519 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature