Frailty and uptake of angiotensin receptor neprilysin inhibitor for heart failure with reduced ejection fraction.

ABSTRACT:

Background

Frail older adults may be less likely to receive guideline-directed medical therapy (GDMT)-renin-angiotensin blockers, beta-blockers, and mineralocorticoid receptor antagonists-for heart failure with reduced ejection fraction (HFrEF). We aimed to examine the uptake of angiotensin receptor neprilysin inhibitor (ARNI) and GDMT in frail older adults with HFrEF.

Methods

Using 2015-2019 Medicare data, we estimated the proportion of beneficiaries with HFrEF receiving ARNI and GDMT each year by frailty status, defined by a claims-based frailty index. Logistic regression was used to identify clinical characteristics associated with ARNI initiation. Cox proportional hazards regression was used to examine the association of GDMT use in 2015 and death or heart failure hospit

SUBMITTER: Lee YC 

PROVIDER: S-EPMC10592538 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature