Identification of complement factor H variants that predispose to pre-eclampsia: A genetic and functional study.

ABSTRACT:

Objective

The objective of the study was to investigate the role of genetic variants in complement proteins in pre-eclampsia.

Design

In a case-control study involving 609 cases and 2092 controls, five rare variants in complement factor H (CFH) were identified in women with severe and complicated pre-eclampsia. No variants were identified in controls.

Setting

Pre-eclampsia is a leading cause of maternal and fetal morbidity and mortality. Immune maladaptation, in particular, complement activation that disrupts maternal-fetal tolerance leading to placental dysfunction and endothelial injury, has been proposed as a pathogenetic mechanism, but this remains unproven.

Population

We genotyped 609 pre-eclampsia cases and 2092 controls from FINNPEC and the national FINRI

SUBMITTER: Lokki AI 

PROVIDER: S-EPMC10592561 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature