Longitudinal changes in Alzheimer's-related plasma biomarkers and brain amyloid.

ABSTRACT:

Introduction

Understanding longitudinal plasma biomarker trajectories relative to brain amyloid changes can help devise Alzheimer's progression assessment strategies.

Methods

We examined the temporal order of changes in plasma amyloid-β ratio ( Aβ42/Aβ40${{\rm A}\beta }_{42}/{{\rm A}\beta }_{40}$ ), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau ratios ( p-tau181/Aβ42$\text{p-tau181}/\mathrm{A}{\beta}_{42}$ , p-tau231/Aβ42$\text{p-tau231}/\mathrm{A}{\beta}_{42}$ ) relative to ¹¹ C-Pittsburgh compound B (PiB) positron emission tomography (PET) cortical amyloid burden (PiB-/+). Participants (n = 199) were cognitively normal at index visit with a median 6.1-year follow-up.

Results

PiB groups exhibited different

SUBMITTER: Bilgel M 

PROVIDER: S-EPMC10592628 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature