A developmentally defined population of neurons in the lateral septum controls responses to aversive stimuli.

ABSTRACT: When interacting with their environment, animals must balance exploratory and defensive behavior to evaluate and respond to potential threats. The lateral septum (LS) is a structure in the ventral forebrain that calibrates the magnitude of behavioral responses to stress-related external stimuli, including the regulation of threat avoidance. The complex connectivity between the LS and other parts of the brain, together with its largely unexplored neuronal diversity, makes it difficult to understand how defined LS circuits control specific behaviors. Here, we describe a mouse model in which a population of neurons with a common developmental origin (Nkx2.1-lineage neurons) are absent from the LS. Using a combination of circuit tracing and behavioral analyses, we found that these neuro

SUBMITTER: Garcia MT 

PROVIDER: S-EPMC10592641 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature