Hippocampal mechanisms resolve competition in memory and perception.

ABSTRACT: Behaving adaptively requires selection of relevant memories and sensations and suppression of competing ones. We hypothesized that these mechanisms are linked, such that hippocampal computations that resolve competition in memory also shape the precision of sensory representations to guide selective attention. We leveraged fMRI-based pattern similarity, receptive field modeling, and eye tracking to test this hypothesis in humans performing a memory-dependent visual search task. In the hippocampus, differentiation of competing memories predicted the accuracy of memory-guided eye movements. In visual cortex, preparatory coding of remembered target locations predicted search successes, whereas preparatory coding of competing locations predicted search failures due to interference. These effec

SUBMITTER: Favila SE 

PROVIDER: S-EPMC10592663 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature