Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy.

ABSTRACT: The rational combination of anticancer agents is critical to improving patient outcomes in cancer. Nonetheless, most combination regimens in the clinic result from empirical methodologies disregarding insight into the mechanism of action and missing the opportunity to improve therapy outcomes incrementally. Deciphering the genetic dependencies and vulnerabilities responsible for synergistic interactions is crucial for rationally developing effective anticancer drug combinations. Hence, we screened pairwise pharmacological interactions between molecular-targeted agents and conventional chemotherapeutics and examined the genome-scale genetic dependencies in gastric adenocarcinoma cell models. Since this type of cancer is mainly chemoresistant and incurable, clinical situations demand effecti

SUBMITTER: Leylek O 

PROVIDER: S-EPMC10592690 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature