Lateral entorhinal cortex subpopulations represent experiential epochs surrounding reward.

ABSTRACT: During goal-directed navigation, "what" information, which describes the experiences occurring in periods surrounding a reward, can be combined with spatial "where" information to guide behavior and form episodic memories^1,2. This integrative process is thought to occur in the hippocampus³, which receives spatial information from the medial entorhinal cortex (MEC)⁴; however, the source of the "what" information and how it is represented is largely unknown. Here, by establishing a novel imaging method, we show that the lateral entorhinal cortex (LEC) of mice represents key experiential epochs during a reward-based navigation task. We discover a population of neurons that signals goal approach and a separate population of neurons that signals goal departure.

SUBMITTER: Issa JB 

PROVIDER: S-EPMC10592707 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature