Restriction of Arginine Induces Antibiotic Tolerance in <i>Staphylococcus aureus</i>.

ABSTRACT: Staphylococcus aureus is responsible for a substantial number of invasive infections globally each year. These infections are problematic because they are frequently recalcitrant to antibiotic treatment, particularly when they are caused by Methicillin-Resistant Staphylococcus aureus (MRSA). Antibiotic tolerance, the ability for bacteria to persist despite normally lethal doses of antibiotics, is responsible for most antibiotic treatment failure in MRSA infections. To understand how antibiotic tolerance is induced, S. aureus biofilms exposed to multiple anti-MRSA antibiotics (vancomycin, ceftaroline, delafloxacin, and linezolid) were examined using both quantitative proteomics and transposon sequencing. These screens indicated that arginine metabolism is involved in an

SUBMITTER: Freiberg JA 

PROVIDER: S-EPMC10592767 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature