Commensal myeloid crosstalk in neonatal skin regulates cutaneous type 17 inflammation.

ABSTRACT: Early life microbe-immune interactions at barrier surfaces have lasting impacts on the trajectory towards health versus disease. Monocytes, macrophages and dendritic cells are primary sentinels in barrier tissues, yet the salient contributions of commensal-myeloid crosstalk during tissue development remain poorly understood. Here, we identify that commensal microbes facilitate accumulation of a population of monocytes in neonatal skin. Transient postnatal depletion of these monocytes resulted in heightened IL-17A production by skin T cells, which was particularly sustained among CD4⁺ T cells and sufficient to exacerbate inflammatory skin pathologies. Neonatal skin monocytes were enriched in expression of negative regulators of the IL-1 pathway. Functional in vivo experiments con

SUBMITTER: Dhariwala MO 

PROVIDER: S-EPMC10592812 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature