Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism.

ABSTRACT: Physical activity is a modifiable lifestyle factor that is associated with a decreased risk for the development of breast cancer. While the exact mechanisms for the reduction in cancer risk due to physical activity are largely unknown, it is postulated that the biological reduction in cancer risk is driven by improvements in inflammation and immune function with exercise. Hematopoietic stem cells (HSCs) are the progenitor for all of the cells of the immune system and are involved in cancer immunosurveillance through differentiation into cytotoxic cell population. In this study, we investigate the role of physical activity (PA) in a spontaneously occurring model of breast cancer over time, with a focus on tumor incidence, circulating and tumor-infiltrating immune cells as well gene expressi

SUBMITTER: Khair L 

PROVIDER: S-EPMC10592839 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature