Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex.

ABSTRACT: The ability of rodents to use visual cues for successful navigation and goal-directed behavior has been long appreciated, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the hippocampus and closely connected entorhinal cortex, whose neurons exhibit characteristic firing patterns corresponding to the animal's location. The medial entorhinal cortex (MEC) receives direct projections from sensory areas in the neocortex, suggesting the ability to encode sensory information. To examine this possibility, we performed high-density recordings of MEC neurons in awake, head-fixed mice presented with simple visual stimuli and assessed the dynamics of sensory-evoked activity. We found a large fracti

SUBMITTER: Dubanet O 

PROVIDER: S-EPMC10592898 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature