MOIRE: A software package for the estimation of allele frequencies and effective multiplicity of infection from polyallelic data.

ABSTRACT: Malaria parasite genetic data can provide insight into parasite phenotypes, evolution, and transmission. However, estimating key parameters such as allele frequencies, multiplicity of infection (MOI), and within-host relatedness from genetic data has been challenging, particularly in the presence of multiple related coinfecting strains. Existing methods often rely on single nucleotide polymorphism (SNP) data and do not account for within-host relatedness. In this study, we introduce a Bayesian approach called MOIRE (Multiplicity Of Infection and allele frequency REcovery), designed to estimate allele frequencies, MOI, and within-host relatedness from genetic data subject to experimental error. Importantly, MOIRE is flexible in accommodating both polyallelic and SNP data, making it adaptabl

SUBMITTER: Murphy M 

PROVIDER: S-EPMC10592951 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature