Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome.

ABSTRACT: The enhancement of associative synaptic plasticity often results in impaired rather than enhanced learning. Previously, we proposed that such learning impairments may result from saturation of the plasticity mechanism making it unavailable to be recruited at the appropriate synapses to support learning (Nguyen-Vu et al., 2017). This hypothesis was based on experimental results from mice lacking two class I major histocompatibility molecules, MHCI H2-K^b and H2-D^b (MHCI K^bD^b-/-), which have enhanced associative long-term depression at the parallel fiber-Purkinje cell synapses in the cerebellum (PF-Purkinje cell LTD). Here we extend this work by testing predictions of the saturation hypothesis in a second mouse line with

SUBMITTER: Shakhawat AM 

PROVIDER: S-EPMC10592955 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature