Deriving Explainable Metrics of Left Ventricular Flow by Reduced-Order Modeling and Classification.

ABSTRACT:

Background

Extracting explainable flow metrics is a bottleneck to the clinical translation of advanced cardiac flow imaging modalities. We hypothesized that reduced-order models (ROMs) of intraventricular flow are a suitable strategy for deriving simple and interpretable clinical metrics suitable for further assessments. Combined with machine learning (ML) flow-based ROMs could provide new insight to help diagnose and risk-stratify patients.

Methods

We analyzed 2D color-Doppler echocardiograms of 81 non-ischemic dilated cardiomyopathy (DCM) patients, 51 hypertrophic cardiomyopathy (HCM) patients, and 77 normal volunteers (Control). We applied proper orthogonal decomposition (POD) to build patient-specific and cohort-specific ROMs of LV flow. Each ROM aggregates a low number

SUBMITTER: Borja MG 

PROVIDER: S-EPMC10593009 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature