Type 1 Diabetes Risk Phenotypes Using Cluster Analysis.

ABSTRACT:

Background

Although statistical models for predicting type 1 diabetes risk have been developed, approaches that reveal clinically meaningful clusters in the at-risk population and allow for non-linear relationships between predictors are lacking. We aimed to identify and characterize clusters of islet autoantibody-positive individuals that share similar characteristics and type 1 diabetes risk.

Methods

We tested a novel outcome-guided clustering method in initially non-diabetic autoantibody-positive relatives of individuals with type 1 diabetes, using the TrialNet Pathway to Prevention (PTP) study data (n=1127). The outcome of the analysis was time to type 1 diabetes and variables in the model included demographics, genetics, metabolic factors and islet autoantibodies. An in

SUBMITTER: You L 

PROVIDER: S-EPMC10593014 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature