Circulating tumor DNA in the immediate post-operative setting.

ABSTRACT:

Background

Circulating tumor DNA (ctDNA) has emerged as an accurate real-time biomarker of disease status across most solid tumor types. Most studies evaluating the utility of ctDNA have focused on time points weeks to months after surgery, which for many cancer types, is significantly later than decision-making time points for adjuvant treatment. In this systematic review, we summarize the state of the literature on the feasibility of using ctDNA as a biomarker in the immediate postoperative period.

Methods

We performed a systematic review evaluating the early kinetics, defined here as three days, of ctDNA in patients who underwent curative-intent surgery across several cancer types.

Results

Among the 2057 studies identified, we evaluated eight cohort studies with ct

SUBMITTER: Efthymiou V 

PROVIDER: S-EPMC10593016 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature