The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal development.

ABSTRACT: Non-coding variants increase risk of neuropsychiatric disease. However, our understanding of the cell-type specific role of the non-coding genome in disease is incomplete. We performed population scale (N=1,393) chromatin accessibility profiling of neurons and non-neurons from two neocortical brain regions: the anterior cingulate cortex and dorsolateral prefrontal cortex. Across both regions, we observed notable differences in neuronal chromatin accessibility between schizophrenia cases and controls. A per-sample disease pseudotime was positively associated with genetic liability for schizophrenia. Organizing chromatin into cis- and trans-regulatory domains, identified a prominent neuronal trans-regulatory domain (TRD1) active in immature glutamatergic neurons during f

SUBMITTER: Girdhar K 

PROVIDER: S-EPMC10593028 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature