Discovery of Ancestry-specific Variants Associated with Clopidogrel Response among Caribbean Hispanics.

ABSTRACT:

Background

High on-treatment platelet reactivity (HTPR) with clopidogrel is predictive of ischemic events in adults with coronary artery disease. Despite strong data suggesting HTPR varies with ethnicity, including clinical and genetic variables, no genome-wide association study (GWAS) of clopidogrel response has been performed among Caribbean Hispanics. This study aimed to identify genetic predictors of HTPR in a cohort of Caribbean Hispanic cardiovascular patients from Puerto Rico.

Methods

Local Ancestry inference (LAI) and traditional GWASs were performed on a cohort of 511 clopidogrel-treated patients, stratified based on their P2Y12 reaction units (PRU) into responders and non-responders (HTPR).

Results

The LAI GWAS identified variants within the CYP2C19 r

SUBMITTER: Yang G 

PROVIDER: S-EPMC10593031 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature