Blood, Gut, and Oral Microbiome in Kidney Transplant Recipients.

ABSTRACT:

Background and objective

Recent reports describe the existence of a blood microbiome profile not associated with an infection state. Given the high impact that the dysbiotic human microbiome appears to have in chronic kidney disease and, in particular, in the outcome of kidney transplant recipients (KTRs), we aimed to explore the variations and correlations of the gut, oral, and blood microbiome of recipients, 3 months after kidney transplantation.

Materials and methods

We conducted a cross-sectional study where the microbiome of stool, saliva, and blood collected from recipients 3 months after kidney transplantation (N = 6) was analyzed by polymerase chain reaction (PCR) amplification and sequencing of the V3-V4 hypervariable regions of the 16S rRNA gene using MiSeq

SUBMITTER: Sampaio S 

PROVIDER: S-EPMC10593307 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature