Motor context modulates substantia nigra pars reticulata spike activity in patients with Parkinson's disease.

ABSTRACT:

Objective

The severity of motor symptoms in Parkinson's disease (PD) depends on environmental conditions. For example, the presence of external patterns such as a rhythmic tone can attenuate bradykinetic impairments. However, the neural mechanisms for this context-dependent attenuation (e.g., paradoxical kinesis) remain unknown. Here, we investigate whether context-dependent symptom attenuation is reflected in single-unit activity recorded in the operating room from the substantia nigra pars reticulata (SNr) of patients with PD undergoing deep brain stimulation surgery. The SNr is known to influence motor planning and execution in animal models, but its role in humans remains understudied.

Methods

We recorded SNr activity while subjects performed cued directional movements i

SUBMITTER: Tekriwal A 

PROVIDER: S-EPMC10593310 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature