Differential effects on TDP-43, piezo-2, tight-junction proteins in various brain regions following repetitive low-intensity blast overpressure.

ABSTRACT:

Introduction

Mild traumatic brain injury (mTBI) caused by repetitive low-intensity blast overpressure (relBOP) in military personnel exposed to breaching and heavy weapons is often unrecognized and is understudied. Exposure to relBOP poses the risk of developing abnormal behavioral and psychological changes such as altered cognitive function, anxiety, and depression, all of which can severely compromise the quality of the life of the affected individual. Due to the structural and anatomical heterogeneity of the brain, understanding the potentially varied effects of relBOP in different regions of the brain could lend insights into the risks from exposures.

Methods

In this study, using a rodent model of relBOP and western blotting for protein expression we showed the different

SUBMITTER: Heyburn L 

PROVIDER: S-EPMC10593467 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature