Differential effect of gastric bypass versus sleeve gastrectomy on insulinotropic action of endogenous incretins.

ABSTRACT:

Objective

Prandial hyperinsulinemia after Roux-en-Y gastric bypass surgery (GB), and to lesser degree after sleeve gastrectomy (SG), has been attributed to rapid glucose flux from the gut and increased insulinotropic gut hormones. However, β-cell sensitivity to exogenous incretin is reduced after GB. This study examines the effect of GB versus SG on prandial glycemia and β-cell response to increasing concentrations of endogenous incretins.

Methods

Glucose kinetics, insulin secretion rate (ISR), and incretin responses to 50-g oral glucose ingestion were compared between ten nondiabetic participants with GB versus nine matched individuals with SG and seven nonoperated normal glucose tolerant control individuals (CN) with and without administration of 200 mg of sitagliptin.

SUBMITTER: Salehi M 

PROVIDER: S-EPMC10593483 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature