Changes in metabolic syndrome and the risk of breast and endometrial cancer according to menopause in Korean women.

ABSTRACT:

Objectives

This study investigated how changes in metabolic syndrome (MetS) are associated with the subsequent risk of breast and endometrial cancer according to menopausal status.

Methods

This cohort study, using data from the National Health Insurance Service database, included women aged ≥40 years who underwent 2 biennial cancer screenings (2009-2010 and 2011-2012) and were followed up until 2020. Participants were grouped into MetS-free, MetS-recovery, MetS-development, and MetS-persistent groups. Menopausal status (premenopausal, perimenopausal, and postmenopausal) was assessed at 2 screenings. Cox proportional hazard regression was used to assess the association between MetS changes and cancer risk.

Results

In 3,031,980 women, breast and endometrial cancers were

SUBMITTER: Tran TXM 

PROVIDER: S-EPMC10593591 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature