Pharmacological characterisation of the effort for reward task as a measure of motivation for reward in male mice.

ABSTRACT:

Rationale

Motivational deficits are a common symptom shared across multiple psychiatric and neurodegenerative disorders. Effort-based decision-making tasks are a translatable method for assessing motivational state. Much of the preclinical validation of the task derives from acute pharmacological manipulations in rats. However, mice currently offer a greater genetic toolkit to study risk genes and phenotypic models. Despite this, there is limited characterisation of their behaviour in this type of motivation task.

Objectives

Here, we investigate the effort for reward (EfR) task as a measure of motivational state in mice using drugs previously shown to modulate effort-based decision-making in rats and humans.

Method

Using male C57bl/6j mice, we test the effects of drug

SUBMITTER: Marangoni C 

PROVIDER: S-EPMC10593616 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature