Continuous home cage monitoring of activity and sleep in mice during repeated paroxetine treatment and discontinuation.

ABSTRACT:

Rationale

Non-invasive home cage monitoring is emerging as a valuable tool to assess the effects of experimental interventions on mouse behaviour. A field in which these techniques may prove useful is the study of repeated selective serotonin reuptake inhibitor (SSRI) treatment and discontinuation. SSRI discontinuation syndrome is an under-researched condition that includes the emergence of sleep disturbances following treatment cessation.

Objectives

We used passive infrared (PIR) monitoring to investigate changes in activity, sleep, and circadian rhythms during repeated treatment with the SSRI paroxetine and its discontinuation in mice.

Methods

Male mice received paroxetine (10 mg/kg/day, s.c.) for 12 days, then were swapped to saline injections for a 13 day disconti

SUBMITTER: Collins HM 

PROVIDER: S-EPMC10593620 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature