Use of the Spirometric "Fixed-Ratio" Underdiagnoses COPD in African-Americans in a Longitudinal Cohort Study.

ABSTRACT:

Background

COPD diagnosis is tightly linked to the fixed-ratio spirometry criteria of FEV₁/FVC < 0.7. African-Americans are less often diagnosed with COPD.

Objective

Compare COPD diagnosis by fixed-ratio with findings and outcomes by race.

Design

Genetic Epidemiology of COPD (COPDGene) (2007-present), cross-sectional comparing non-Hispanic white (NHW) and African-American (AA) participants for COPD diagnosis, manifestations, and outcomes.

Setting

Multicenter, longitudinal US cohort study.

Participants

Current or former smokers with ≥ 10-pack-year smoking history enrolled at 21 clinical centers including over-sampling of participants with known COPD and AA. Exclusions were pre-existing non-COPD lung disease, except for a history of asthma.

M

SUBMITTER: Regan EA 

PROVIDER: S-EPMC10593702 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature