RNA modification regulator DDC in endometrial cancer affects the tumor microenvironment and patient prognosis.

ABSTRACT: Uterine corpus endometrial carcinoma (UCEC) is infiltrated by immune cells, which are involved in the growth and proliferation of malignant tumors and resistance to immunotherapy. This study suggested that RNA modification regulators played an important role in the development and prognosis of UCEC. Many studies confirmed that RNA modification played an essential role in tumor immune regulation, and abnormal RNA modification contributed to tumorigenesis and cancer progression. Based on the RNA modification regulatory factors, the UCEC samples from TCGA (The Cancer Genome Atlas) were classified into two clusters, namely Cluster A and Cluster B, using unsupervised consensus clustering. We obtained DEG (differentially expressed genes) between the two clusters, and constructed a risk model of

SUBMITTER: Zhao H 

PROVIDER: S-EPMC10593861 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature