Increased Aperiodic Neural Activity During Sleep in Major Depressive Disorder.

ABSTRACT:

Background

In major depressive disorder (MDD), patients often express subjective sleep complaints, while polysomnographic studies report only subtle alterations of the electroencephalographic signal. We hypothesize that differentiating the signal into its oscillatory and aperiodic components may bring new insights into our understanding of sleep abnormalities in MDD. Specifically, we investigated aperiodic neural activity during sleep and its relationships with sleep architecture, depression severity, and responsivity to antidepressant treatment.

Methods

Polysomnography was recorded in 38 patients with MDD (in unmedicated and 7-day-medicated states) and 38 age-matched healthy control subjects (N= 76). The aperiodic power component was calculated using irregular

SUBMITTER: Rosenblum Y 

PROVIDER: S-EPMC10593867 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature