Gpr88 Deletion Impacts Motivational Control Without Overt Disruptions to Striatal Dopamine.

ABSTRACT:

Background

Disrupted motivational control is a common-but poorly treated-feature of psychiatric disorders, arising via aberrant mesolimbic dopaminergic signaling. GPR88 is an orphan G protein-coupled receptor that is highly expressed in the striatum and therefore well placed to modulate disrupted signaling. While the phenotype of Gpr88 knockout mice suggests a role in motivational pathways, it is unclear whether GPR88 is involved in reward valuation and/or effort-based decision making in a sex-dependent manner and whether this involves altered dopamine function.

Methods

In male and female Gpr88 knockout mice, we used touchscreen-based progressive ratio, with and without reward devaluation, and effort-related choice tasks to assess motivation and cost/benefit de

SUBMITTER: Spark DL 

PROVIDER: S-EPMC10593871 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature