Persistent Brain Connectivity Changes in Healthy Volunteers Following Nitrous Oxide Inhalation.

ABSTRACT:

Background

Nitrous oxide holds promise in the treatment of major depressive disorder. Its psychotropic effects and NMDA receptor antagonism have led to comparisons with ketamine. Despite longstanding use, persistent effects of nitrous oxide on the brain have not been characterized.

Methods

Sixteen healthy volunteers were recruited in a double-blind crossover study. In randomized order, individuals underwent a 1-hour inhalation of either 50% nitrous oxide/oxygen or air/oxygen mixtures. At least two 7.5-minute echo-planar resting-state functional magnetic resonance imaging scans were obtained before and at 2 and 24 hours after each inhalation (average 130 min/participant). Using the time series of preprocessed, motion artifact-scrubbed, and nuisance covariate-regressed imaging

SUBMITTER: Palanca BJA 

PROVIDER: S-EPMC10593877 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature