Schizophrenia Polygenic Risk During Typical Development Reflects Multiscale Cortical Organization.

ABSTRACT:

Background

Schizophrenia is widely recognized as a neurodevelopmental disorder. Abnormal cortical development in otherwise typically developing children and adolescents may be revealed using polygenic risk scores for schizophrenia (PRS-SCZ).

Methods

We assessed PRS-SCZ and cortical morphometry in typically developing children and adolescents (3-21 years, 46.8% female) using whole-genome genotyping and T1-weighted magnetic resonance imaging (n = 390) from the PING (Pediatric Imaging, Neurocognition, and Genetics) cohort. We contextualized the findings using 1) age-matched transcriptomics, 2) histologically defined cytoarchitectural types and functionally defined networks, and 3) case-control differences of schizophrenia and other major psychiatric disorders derived fro

SUBMITTER: Kirschner M 

PROVIDER: S-EPMC10593879 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature