S100a9 Protects Against the Effects of Repeated Social Defeat Stress.

ABSTRACT:

Background

Posttraumatic stress disorder, a consequence of psychological trauma, is associated with increased inflammation and an elevated risk of developing comorbid inflammatory diseases. However, the mechanistic link between this mental health disorder and inflammation remains elusive. We previously found that S100a8 and S100a9 messenger RNA, genes that encode the protein calprotectin, were significantly upregulated in T lymphocytes and positively correlated with inflammatory gene expression and the mitochondrial redox environment in these cells. Therefore, we hypothesized that genetic deletion of calprotectin would attenuate the inflammatory and redox phenotype displayed after psychological trauma.

Methods

We used a preclinical mouse model of posttraumatic stress disorde

SUBMITTER: Moshfegh CM 

PROVIDER: S-EPMC10593888 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature