Hippocampal Network Dysfunction in Early Psychosis: A 2-Year Longitudinal Study.

ABSTRACT:

Background

Hippocampal abnormalities are among the most consistent findings in schizophrenia. Numerous studies have reported deficits in hippocampal volume, function, and connectivity in the chronic stage of illness. While hippocampal volume and function deficits are also present in the early stage of illness, there is mixed evidence of both higher and lower functional connectivity. Here, we use graph theory to test the hypothesis that hippocampal network connectivity is broadly lowered in early psychosis and progressively worsens over 2 years.

Methods

We examined longitudinal resting-state functional connectivity in 140 participants (68 individuals in the early stage of psychosis, 72 demographically similar healthy control individuals). We used an anatomically driven approa

SUBMITTER: Avery SN 

PROVIDER: S-EPMC10593896 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature