Locus coeruleus pathology is associated with cerebral microangiopathy at autopsy.

ABSTRACT:

Introduction

We investigated the link between locus coeruleus (LC) pathology and cerebral microangiopathy in two large neuropathology datasets.

Methods

We included data from the National Alzheimer's Coordinating Center (NACC) database (n = 2197) and Religious Orders Study and Rush Memory and Aging Project (ROSMAP; n = 1637). Generalized estimating equations and logistic regression were used to examine associations between LC hypopigmentation and presence of cerebral amyloid angiopathy (CAA) or arteriolosclerosis, correcting for age at death, sex, cortical Alzheimer's disease (AD) pathology, ante mortem cognitive status, and presence of vascular and genetic risk factors.

Results

LC hypopigmentation was associated with higher odds of overall CAA in the NACC dataset, lep

SUBMITTER: Freeze WM 

PROVIDER: S-EPMC10593911 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature