Direct and Indirect Genetic Effects on Aggression.

ABSTRACT:

Background

Family members resemble each other in their propensity for aggression. In twin studies, approximately 50% of the variance in aggression can be explained by genetic influences. However, if there are genotype-environment correlation mechanisms, such as environmental manifestations of parental and sibling genotypes, genetic influences may partly reflect environmental influences. In this study, we investigated the importance of indirect polygenic score (PGS) effects on aggression.

Methods

We modeled the effect of PGSs based on 3 genome-wide association studies: early-life aggression, educational attainment, and attention-deficit/hyperactivity disorder (ADHD). The associations with aggression were tested in a within- and between-family design (37,796 measures from 7740

SUBMITTER: van der Laan CM 

PROVIDER: S-EPMC10593934 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature