Association between post-operative hPG₈₀ (circulating progastrin) detectable level and worse prognosis in glioblastoma.

ABSTRACT:

Background

Patients with glioblastomas have a dismal prognosis, and there is no circulating predictive or prognostic biomarker. Circulating progastrin, hPG₈₀, is a tumor-promoting peptide present in the blood of patients with various cancers that has been shown to have prognostic value. We evaluated the prognostic value of plasma hPG₈₀ in patients with isocitrate dehydrogenase-wild type glioblastoma after surgery.

Patients and methods

A multicentric retrospective study in glioblastoma patients treated with standard radio-chemotherapy was conducted. The hPG₈₀ levels were measured in plasma EDTA samples collected after surgery with an ELISA DxPG80.lab kit (Biodena Care, Montpellier, France), which has a detection threshold of 1.2 pM. The relati

SUBMITTER: Doucet L 

PROVIDER: S-EPMC10594012 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature