Efficient macrocyclization facilitated by skeleton preorganization.

ABSTRACT: Reported here is the efficient macrocyclization facilitated by skeleton preorganization. A pyridylcarbazole macrocycle and a phenylpyridylcarbazole macrocycle was synthesized in yield up to 75%. Single-crystal structures and theoretic computation uncovered that the skeleton preorganization promoted the formation of cyclization-favorable conformation of noncyclic precursors via π⋯π interactions. This result provided a new approach for the efficient syntheses of macrocycles.

SUBMITTER: Xu RY 

PROVIDER: S-EPMC10594055 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature