Prenatal Lead Exposure, Genetic Factors, and Cognitive Developmental Delay.

ABSTRACT:

Importance

Although the effects of lead (Pb) exposure on neurocognition in children have been confirmed, the individual associations of prenatal Pb exposure and its interaction with genetic factors on cognitive developmental delay (CDD) in children remain unclear.

Objective

To investigate the association of prenatal Pb exposure and its interaction with genetic factors with CDD risk.

Design, setting, and participants

Women in Wuhan, China, who had an expected delivery date between March 2014 and December 2017, were recruited for this prospective cohort study. Children were assessed for cognitive development at approximately 2 years of age (March 2016 to December 2019). Maternal venous blood, cord blood, and venous blood from children were collected in a longitudinal fo

SUBMITTER: Jia Z 

PROVIDER: S-EPMC10594149 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature