Characterization of pyridylpiperazine-based efflux pump inhibitors for Acinetobacter baumannii.

ABSTRACT:

Objectives

In Acinetobacter baumannii, multidrug efflux pumps belonging to the resistance-nodulation-division (RND) superfamily result in decreased antibiotic susceptibility. Improving the activity of current antibiotics via efflux pump inhibitors (EPIs) represents an attractive alternative approach to control this bacterium. Pyridylpiperazines (PyrPips) are a new class of EPIs that can effectively inhibit the Escherichia coli RND efflux pump AcrAB-TolC and boost the activity of several antibiotics. Here we have evaluated and characterized whether the PyrPip chemical family is also able to boost antibiotic activity through inhibition of the RND efflux pumps in A. baumannii.

Methods

Comparative structural modelling and docking, structure-activity relation

SUBMITTER: Jimenez-Castellanos JC 

PROVIDER: S-EPMC10594211 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature