Noncoding RNA Profile in Reovirus Treated KRAS-Mutated Colorectal Cancer Patients.

ABSTRACT:

Purpose

To investigate the alterations in the expression of noncoding, micro, and small RNA expression during treatment with oncolytic reovirus in KRAS-mutated colorectal cancer.

Methods

Oncolytic reovirus treatment was administered in phase 1 clinical trial (NCT01274624) for 5 days every 28 days, and blood samples were collected before the administration of the reovirus and 48 h, 8 days, and 15 days after its administration on day 1. Data from the blood samples were sorted using Transcriptome Analysis Software (TAC) 4.0, where a two-tailed t-test and a fold change filter were used to ascertain which sample signals had a statistically significant relative fold change of greater than 2 at multiple timepoints before or after oncolytic reovirus administration.

SUBMITTER: Saperstein R 

PROVIDER: S-EPMC10594459 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature