Catalytic C-H Trifluoromethylation of Arenes and Heteroarenes via Visible Light Photoexcitation of a Co(III)-CF₃ Complex.

ABSTRACT: A cobalt photocatalyst for direct trifluoromethylation of (hetero)arene C(sp²)-H bonds is described and shown to operate via visible light activation of a Co-CF₃ intermediate, which functions as a combined chromophore and organometallic reaction center. Chemical oxidations of previously reported (OCO)Co complexes containing a redox-active [OCO] pincer ligand afford a Co-CF₃ complex two oxidation states above Co(II). Computational and spectroscopic studies are consistent with formulation of the product as [(OCO^•)Co^III(CF₃)(THF)(OTf)] (II) containing an open-shell [OCO^•]^1- radical ligand bound to a S = 0 Co(III) center. II is thermodynamically stable, but exposure to blue (440 nm) lig

SUBMITTER: Kuehner CS 

PROVIDER: S-EPMC10594583 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature