NRF2/ARE mediated antioxidant response to glaucoma: role of glia and retinal ganglion cells.

ABSTRACT: Glaucoma, the second leading cause of irreversible blindness worldwide, is associated with age and sensitivity to intraocular pressure (IOP). We have shown that elevated IOP causes an early increase in levels of reactive oxygen species (ROS) in the microbead occlusion mouse model. We also detected an endogenous antioxidant response mediated by Nuclear factor erythroid 2-Related Factor 2 (NRF2), a transcription factor that binds to the antioxidant response element (ARE) and increases transcription of antioxidant genes. Our previous studies show that inhibiting this pathway results in earlier and greater glaucoma pathology. In this study, we sought to determine if this endogenous antioxidant response is driven by the retinal ganglion cells (RGCs) or glial cells. We used Nrf2^fl/fl

SUBMITTER: Naguib S 

PROVIDER: S-EPMC10594672 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature